不同剂量纳络酮治疗眩晕症的临床观察

Clinical observation on different dose naloxon in the treatment of vertigo

目的探讨不同剂量纳络酮治疗眩晕症的疗效及起效、缓解时间。方法将118例眩晕症病人随机分为3组:对照组39例,小剂量纳络酮组39例,大剂量纳络酮组40例。观察患者症状缓解情况及药物起效、缓解时间。结果大、小剂量纳络酮组缓解率为72.50%和61.54%,总有效率为95.00%和92.31%,均高于对照组的缓解率41.03%和总有效率69.23%,其中总有效率两组较对照组均差异有统计学显著意义(P<0.05)。起效、缓解时间大剂量纳络酮组(1.72±1.70d、1.79±1.31d)少于对照组(2.27±1.91d、3.59±1.69d)和小剂量纳络酮组(2.00±1.90d、3.31±1.79d),且均差异有统计学显著意义(P<0.05)。结论纳络酮治疗眩晕症疗效好,而且大剂量纳络酮起效快。

Objective To discuss the efficacy, onset time of drug effect and symptom remission time of different dose naloxon in the treatment of vertigo. Methods One hundred and eighteen patients with vertigo were divided into 3 groups randomly. 39 patients were assigned to control group, 39 patients to the small dose naloxon group, 40 patients to the large close naloxon group. The condition of symptoms remission and the onset time of drug effect and symptom remission time were observed. Results The remission rate of the large close naloxon group was 72. 5% , totally effective rate was 95.00%. And the remission rate of the small dose group was 61.54% , totally effective rate was 92. 31%. Their remission rate and totally effective rate were all higher than control group（41.03% ,69. 23% ）. The totally effective rate between the naloxon groups and the control group have significantly difference （ P 〈 0. 05 ）. About the onset time of drug effect and symptom remission time, the large dose naloxon group（ 1.72 ± 1.70,1.79 ± 1.31 days）was significantly faster than control group（2.27 ± 1.91 、3.59± 1.69 days）and the small dose naloxon group（2.00 ±1.90、3. 31 ±1.79 days）（P〈0.05）. Conclusion The curative effect of naloxon in the treatment of vertigo is significant, and the effects of large dose naloxon is faster.