水痘-带状疱疹病毒与皮损中各类细胞关系的电镜观察

Ultrastructural study on the host relationship and affinity between VZV and different cells in lesions of patients with varicella and herpes zoster

为了探讨（水痘－带状疱疹病毒）（ＶＺＶ）与皮损中各类细胞之间的宿主关系和亲和性，用透射电镜观察了水痘、带状疱疹患者皮损，结果发现ＶＺＶ在皮肤的宿主细胞范围广泛，包括表皮细胞、成纤维细胞、血管内皮与周皮细胞、许旺细胞以及巨噬细胞和肥大细胞，其中对表皮细胞、成纤维细胞的亲和性最强，与中性粒细胞和淋巴细胞无宿主关系。中性粒细胞在皮肤局部显示出较强的吞噬、消化ＶＺＶ现象。

To study the host relationship and affinity between the varicella zoster virus (VZV) and various kinds of cells in the lesions,the skin lesions of varicella and herpes zoster were observed with transmission electron microscope. The results showed that the host cells of VZV were of different kinds,which included epidermal cells,fibroblasts,endothelial cells and pericytes of the blood vessels in thedermis, Schwanns cells,macrophages and mast cells.Among them,The affinity of VZV with epidermal cells and fibroblasts was the strongest,and no host relationship with neutrophils and lymphocytes was found. The neutrophils showed and obvious phenomenon to phagocytose and digest VZV,and the macrophages had role both in defending and spreading the viruses.