芪参益气滴丸治疗慢性乙型肝炎的疗效观察

Therapeutic effects of Qishenyiqi on patients with chronic hepatitis B

目的:观察芪参益气滴丸治疗肝功能异常的慢性乙型肝炎的疗效和安全性。方法:选取80例肝功能异常的慢性乙肝患者,随机分成研究组和对照组各40例,研究组口服芪参益气滴丸每次0.5g,tid,共12周,对照组口服护肝宁片每次4片,tid,疗程12周。对两组进行比较,评价治疗前后患者临床症状和肝功能与肝纤维化指标的恢复情况,同时记录不良反应。结果:治疗后,研究组和对照组的患者症状均有不同程度改善,其中研究组有腹胀和肝区不适患者的症状改善率明显高于对照组(P<0.05)。两组患者治疗后的肝功能及血清纤维化指标与治疗前比较均得到显著改善,但两组间比较差异无显著性意义(P>0.05)。研究组总有效率达77.5%,对照组为70%,两组比较差异无显著性意义(P>0.05)。且都无明显的不良反应。结论:芪参益气滴丸治疗肝功能异常的慢性乙型肝炎患者安全、有效。

Objective： To evaluate the efficacy of Chinese herbs compound Qishenyiqi for patients with chronic hepatitis B （CHB） . Methods ： Eighty patients with chronic hepatitis B （ abnormal ALT level ） were randomly divided into two different groups; The patients of trial group （n = 40） were treated with Qishenyiqi （0. 5q, tid） for 12 weeks, and the controlled group （n =40） were treated with Chinese herbs compound Huganning pills （4#, tid）. Before and after treatment for 4, 8 and 12 weeks, the serum parameters of liver function and fibrosis were detected for the patients of both groups. Results： The improvement rate of the belly inflation and right-flank malaise in trial group were obvious higher than control group （ P 〈 0. 05 ） . After treatment, both liver function and fibrosis parameters were significantly improved, and there were no significant difference between the two groups on the gross efficacy. No serious adverse events were reported in both groups. Conclusion： Qishenyiqi has significant therapeutic effects on chronic heaptitis B, which was showed significantly improving some manifestations and the parameters of liver function and fibrosis, and it is safety.