摘要
目的观察益气活血复方(YQHXFF)对兔颈动脉内皮损伤后血管内膜增生及血管细胞黏附分子-1(VCAM-1)表达的影响。方法将雄性新西兰白兔28只,随机分为3组,空白组给予普通饲料8周;模型组和益气活血复方组给予高脂喂养6周后,用球囊拉伤法建立兔颈总动脉内皮损伤模型,第8周末处死动物,免疫组化法检测损伤处颈总动脉组织中VCAM-1表达,HE染色观察颈动脉组织病理形态学改变。结果与模型组对比,益气活血复方可明显抑制损伤后的动脉内膜增殖反应,下调损伤局部VCAM-1的表达水平(P<0.05)。结论益气活血复方可抑制球囊损伤后动脉内膜增殖反应,其机制可能与下调VCAM-1表达有关。
Objective To observe the effects of YQHXFF on intima hyperplasia and vascular cell adhesion molecule-1（VCAM-1） in rabbits after percutaneous transluminal coronary angioplasty （PTCA）. Methods Twenty-eight male New Zealand white rabbits were randomly divided into control group, model group and YQHXFF intervention group. A model of re-stenosis was established by injuring common carotid artery of rabbits on cholesterol. After 8 weeks, VCAM-1 was measured by immunohistochemistry, and pathologic changes were observed with H＆E staining. Results Compared to the model group, the expression of VCAM-1 was markedly decreased and intima hyperplasia was significantly improved in YQHXFF intervention group. Conclusion YQHXFF can inhibit the expression of VCAM-1 and improve intima hyperplasia after PTCA.
出处
《军医进修学院学报》
CAS
2010年第1期75-77,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
益气活血复方
颈动脉损伤
细胞黏附分子
YQHXFF
Carotid Artery Injuries
Cell Adhesion Molecules（VCAM- 1）
