美托洛尔对舒张性心力衰竭兔神经内分泌系统的影响

Effect of metoprolol on neuroendocrine system of rabbits with diastolic heart failure

目的研究美托洛尔对舒张性心力衰竭兔神经内分泌系统的影响。方法雄性新西兰兔30只随机分为3组:手术组在右侧肾动脉上1cm处行腹主动脉缩窄术;手术治疗组从术后第1天起应用美托洛尔治疗;假手术组作为对照组。术后观察心衰的临床表现,定期复查超声心动图,并监测全身和心肌局部AngⅡ、ET-1、NE和NT-proBNP变化。结果手术治疗组的心衰发生率明显低于手术组,心室结构和功能达到显著改善,血清AngⅡ(25.57vs38.16,P<0.01)、ET-1(21.14vs35.96,P<0.01)和血清与心肌NE(97.90vs128.51,P<0.01;11.77vs17.28,P<0.05)、NT-proBNP(221.92vs305.76,P<0.01;24.33vs30.53,P<0.05)显著降低。结论美托洛尔可有效抑制DHF兔的全身和心肌局部神经内分泌系统激活。

Objective To study the effect of metoprolol on neuroendocrine system of rabbits with diastolic heart failure. Methods Thirty New-Zealand rabbits were randomly assigned to operation group with constriction of abdominal aorta lcm just above the right renal artery, treatment group receiving metoprolol from the first day after operation, and sham operation group serving as a control group. Changes in clinical manifestations of heart failure were carefully observed. Cardiac structure and function were investigated by regular echocardiography. Systematic and cardiac levels of local Ang Ⅱ ,ET-1, NE, and NT-proBNP were measured. Results The incidence of heart failure was obviously lower in treatment group than in operation group. The structure and function of heart were markedly improved. The serum levels of Ang Ⅱ, ET-1, NE and NT-proBNP both in serum and myocardium were significantly lower in treatment group than in control group （25.57 vs 38.16, 21.14 vs 35.96, 97.90 vs 128.51, P〈0.01; 11.77 vs 17.28, 221.92 vs 305.76, 24.33 vs 30.53, P〈0.05）. Conclusion Metoprolol can effectively inhibit the activation of neuroendocrine system of rabbits with diastolic heart failure.