期刊文献+

120例老年乳腺癌患者临床特征及预后分析 被引量:3

下载PDF
导出
摘要 目的探讨老年乳腺癌的临床特征及预后因素。方法回顾性分析120例老年乳腺癌患者的临床资料及治疗效果。结果肿瘤分期、腋窝淋巴结状态、C-erbB-2状态、病理类型、有无进行手术及术后有无内分泌治疗为影响老年乳腺癌预后的因素,而ER/PR阴性,术后辅助化疗、术后辅助放疗对老年乳腺癌总生存率没有影响。经COX多因素分析发现,肿瘤分期、C-erbB-2状态及有无进行手术为影响预后的独立因素。结论老年乳腺癌具有独特的生物学特点,病理类型主要为浸润性导管癌;激素受体阳性表达率高;C-erbB-2阳性表达率低;生存期较其他年龄组长。治疗应选择以手术为主的综合治疗,其中内分泌治疗占有重要地位。
机构地区 福建省肿瘤医院
出处 《福建医药杂志》 CAS 2009年第6期21-22,共2页 Fujian Medical Journal
  • 相关文献

参考文献5

  • 1Gennari R, Curigliano G, Rotmensz N, et at. Breast carcinoma in elderly women : features of disease presentation, choice of local and systemic treatment s compared with younger postmenopausal patients[J]. Cancer, 2004, 101 (6): 1302-1310.
  • 2Veronesi U, Luini A, Delvecchio M, et al. Radiotherapy after breast-preserving surgery in woman with localized cancer of the breast [J]. N Engl J Med, 1993, 328 (6): 1587-1591.
  • 3张斌.老年人乳腺癌[J].中国癌症杂志,2005,15(5):422-425. 被引量:40
  • 4DeMichele A, Putt M, Zhang Y, et al. Older age predicts a decline in adjuvant chemotherapy recommendations for patients with breast carcinoma: evidence from a tertiary care cohort for chemotherapy eligible patients [J]. Cancer, 2003, 97 ( 9 ): 2150-2159.
  • 5Hughes KS, Schnaper LA, Berry D, et al. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or order with early breast cancer [J]. N Engl J Med, 2004, 351 (3) : 971-977.

二级参考文献11

  • 1Fisher B, Aderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy and radiation for the treatment of invasive breast cancer[J]. N Eng J Med,2002 ,347 (16 ) :1233-1241.
  • 2Hughes KS, Schnaper LA, Berry D, et al. Comparison of lunmpectomy plustamoxifen with and without radiotherapy in women 70 years of age or older who have clinical stage I, estrogen receptor positive breast carcinoma[ J ]. Proc Am Soc Clin Oncol,2001,20:24a.
  • 3Vlastos G, Mirza NQ, Mric F, et al. Breast Conservation therapy as a treatment option for the elderly:the M. D. Anderson experience [ J ]. Cancer,2001,92 ( 5 ): 1092-1100.
  • 4Kunkler IH, Jack W, Prescott R, et al. Postoperative breast irradiation:new trials needed in older patients [ J ]. J Clin Oncol ,2003,21 ( 9 ): 1893-1894.
  • 5Early Breast Cancer Trialists' Collaborative Group. Polychemotherapy for early breast cancer: an overview of the randomized trials[J]. Lancet,1998,352(9312) :930-942.
  • 6Dellapasqua S, Crivellari F, Hamilton A, et al. Tailored chemotherapy trial for women at advanced age with endocrine nonresponsive breast cancer: the CASA Trial[ J]. The Breast,2005,14( Suppl 1 ): S39.
  • 7Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomized trials [ J].Lancet, 1998,351 (9141 ): 1451-1467.
  • 8Preece PE, Wood RA, Mackie CR, et al. Tamoxifen as initial sole treatment of localized breast cancer in elderly women: a pilot study [ J ]. Br Med J Clin Res, 1982,284 ( 6319 ): 869 -870.
  • 9Baum M, Buzdar AU, Cuzick J, et al. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC trial efficacy and safety update analyses[ J]. Cancer,2003,98(9 ): 1802-1810.
  • 10Thurlimann B. BIG 1-98: A Prospective randomized double-blind double-dummy phase Ⅲ study to evaluate letrozole as adjuvant endocrine therapy for postmenopausal women with receptor-positive breast cancer[ J ]. The Breast,2005,14 (Suppl 1 ) :S4.

共引文献39

同被引文献14

引证文献3

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部