某三级甲等医院高血压病患者用药情况调查

Survey of medication on patients with essential hypertension in a upper first-class hospital

目的通过回顾性调查某三级甲等医院2003年与2007年原发性高血压住院病例高血压药物治疗情况,探讨其合理性及用药趋势。方法随机抽取某三级甲等医院2003年与2007年原发性高血压住院病例各300例,按年份分为2003年组与2007年组,统计分析用药情况。结果该院抗高血压药物均以钙拮抗剂(CCB)、血管紧张素转化酶抑制剂(ACEI)为主;联合用药是主要的降压手段,以二联疗法为主。与2003年组比较,2007年组β-受体阻滞剂、血管紧张素Ⅱ受体阻滞剂(ARB)、新型复方降压制剂使用率均增加(29.0%vs 16.7%,30.0%vs 8.3%,4.0%vs 0,均P<0.05);利尿剂、ACEI使用率降低(10.3%vs 24.3%,37.7%vs 49.0%,均P<0.05);联合用药比例增加(57.3%vs 46.7%,P<0.05)。结论该院原发性高血压住院患者的药物治疗基本符合国内外高血压防治指南的推荐用药,但利尿剂应用相对不足,联合降压治疗是目前高血压治疗的趋势。

Objective To explore the rationality and tendency of medications for essential hypertension in Fujian Provincial Hospital in 2003 and 2007, respectively. Methods Three hundred patients with essential hypertension were taken into study in 2003 and in 2007, respectively. Statistical analysis was made to the medications in the two groups. Results Calcium channel blockers （CCB） and angiotensin converse enzyme inhibitor （ACEI） were the main antihypertension drugs that used both in 2003 and in 2007. The combined medication was in the majority for blood-pressure control. Compared with Group 2003, the use of β-blockers, angiotensin Ⅱ receptor blocker （ARB）, and new type compound antihypertensive drug were increased significantly in Group 2007 （29.0% vs 16.7%, 30.0% vs 8.3%, 4.0% vs 0, respectively, P〈0.05）, while the use of diuretics and ACEI were decreased （10.3% vs 24.3%, 37.7% vs 49.0%, respectively, P〈0.05）. The application of the combined medication were increased remarkably between the two groups （46.7% vs 57.3%, P〈0. 05）. Conclusion The antihypertensive treatment in inpatients with essential hypertension basically meets the standards recommended by Guidelines for Prevention and Treatment of Hypertension at home and aboard. But diuretic usage is relatively low in the hospital. Combination therapy is the tendency for hypertension treatment either now or in the future.