MTS1/p16、MTS2/p15基因与脑胶质瘤
摘要
脑胶质瘤是中枢神经系统最常见的恶性肿瘤,其致死率居神经系统恶性肿瘤之首。随着分子生物学的研究进展,人们已揭示出肿瘤的发生是遗传物质改变而致的多步骤、多基因事件的结果,癌基因激活以及抑癌基因的缺失或失活是细胞癌变的分子基础,它引起基因的转录和翻译功能的...
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第4期389-390,共2页
Chinese Journal of Clinical and Experimental Pathology
参考文献21
-
1Kamb A, Gruis NA, Weaver-Feldhaus J, et al. A cell cycle regulator potentially involved in genes of many tumor types.Science, 1994,264:436.
-
2Serrano M, Hanno GJ, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin-CDK4. Nature, 1993,366:704.
-
3Hannon GJ, Beach. p15 (INK4 B) is a potential effector of TGF-beta induced cell cycle arrest Nature, 1994,371: 257.
-
4Hunter T, Pines J. Cyclins and cancer I:cydin D and CDK inhibitor come of age. Cell, 1994,79:573.
-
5Jen J, Harper W, Bigner SH, et al. Deletion of p16 and pl5 in brain tumors, Cancer Res, 1994,54:6353.
-
6Dreyling MH, Bohlander Sk, Adeyanju MQ, et al. Detection of CDKN2 deletions in tumor cell lines and primary glioma by interphase fluorescence in situ hybridization. Cancer Res,1995,55:984.
-
7Moulton T, Samara G, Chung W, et al. MTS1/pl6/CDKN2 lesions in primary glioblastoma multiforme.Am J Pathol,1995,146:613.
-
8Walker DG, Duan W, Popovic EA, et al. Homozygous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytomas. Cancer Res, 1995,55:20.
-
9Ueki K, Rubio MP, Ramesh V, et al. MTS1/CDKN2 gene mutations are rare in primery human astrocytomas with ailelic loss of chromosome 9P. Hum Mol Genet, 1994,3:1841.
-
10Hussussian CJ, Struewing JP, Goldstein AM, et al. Germline p16 mutations in familial melanoma. Nature Genet, 1994,8:51.
-
1周春晓,孙建衡,陆士新,刘海玲,晁红霞.子宫内膜癌中MTS1/p16基因甲基化的研究[J].中华肿瘤杂志,2000,22(5):428-429.
-
2白华,曲陆荣,王敬云.子宫内膜癌中MTS1/p16基因的表达及临床意义初探[J].中国实用妇科与产科杂志,2001,17(11):671-672. 被引量:9
-
3冯玉梅,毛慧生,刘红,傅西林,吕阿娟,杨毅.乳腺癌MTS1/p16基因缺失及表达异常的初步研究[J].中国肿瘤临床,1998,25(9):660-662. 被引量:3
-
4周春晓,孙建衡,陆士新,刘海玲,苏涛,金顺钱,盛修贵.子宫内膜癌中MTS1/p16基因缺失的研究[J].中华肿瘤杂志,1997,19(6):404-406. 被引量:26
-
5白学章,高欣,李振芬,高玉花,卢虹,魏岚,付茹俊.食管癌MTS_1/p16基因表达的研究[J].中国肿瘤临床与康复,2004,11(4):298-299.
-
6张平,吴清泉.抑癌基因MTS1/p16的缺失与胃癌生物学特性的关系[J].临床肿瘤学杂志,2001,6(1):23-24. 被引量:2
-
7王贵和,赵铁军,夏飞,孙学士.MTS_1/p16基因表达与胆囊癌淋巴结转移相关性研究[J].中国肿瘤临床,2000,27(3):225-226.
-
8陈晓峰,丁嘉安,高文,易祥华,王律,李化.原发性非小细胞肺癌中MTS2/p15的表达及临床意义[J].中国肿瘤临床与康复,2002,9(5):19-21.
-
9王贵和,赵铁军,夏飞,桑卫东.MTS_1/p16基因异常表达与胆道恶性肿瘤生物学行为关系[J].肿瘤研究与临床,1999,11(5):310-311.
-
10王春雷,黄志强,王燕生,刘海玲.结直肠癌组织中MTS1/p16基因表达检测的意义[J].解放军医学杂志,2001,26(12):902-903.