高血压病患者动态血压节律变化与尿微量白蛋白及臂踝脉搏波传导速度的关系

Relationship Between Ambulatory Blood Pressure Rhythm and Microalbuminuria, Brachial-ankle Pulse Wave Velocity in Essential Hypertensive Patients

【目的】研究高血压痛患者动态血压节律变化与尿微量白蛋白（MAU）、臂踝脉搏波传导速度（baPWV）的关系。【方法】根据24h动态血压监测结果，高血压病患者中杓型血压和非杓型血压组各40例，每例均行放免法测定MAU及用动脉硬化自动测量仪检测baPWV。【结果】与杓型血压组相比，非杓型血压组夜间平均收缩压、夜间平均舒张压、MAU、baPWV均增高（P〈0．05或P〈0．01），而白天平均收缩压、白天平均舒张压比较差异无显著性（P〉0．05）。【结论】高血压病患者中非杓型血压者血压昼夜节律变化大，更易发生动脉硬化等靶器官损害。

[Objective]To explore 24-hour ambulatory blood pressure rhythm and its relationship to microalbuminuria（MAU） and brachial-ankle pulse wave velocity（baPWV）in essential hypertensive patients. [Methods] Hypertensive patients were divided into two groups based on their 24-hour ambulatory blood pressure rhythm. Both dipper group（ n =40） and non-dipper group（ n =40） received the measurement of MAU and baPWV. [Results] Compared with the dipper group, the night mean systolic and diastolic blood pressure, MAU and baPWV increased significantly in the non dipper group （ P 〈0. 05 or P 〈0.01）, but no statistical difference in the day mean systolic and diastolic blood pressure was found（ P〉0.05） . [Conclusion] Hypertensive patients with abnormal circadian blood pressure rhythm have more severe arteriosclerotic target organ damages.