摘要
【目的】了解111崎病(KD)患儿的流行病学特征,探讨KD合并冠状动脉病变(CAL)的危险因素。【方法】回顾性分析72例KD住院患儿的病例资料,对可能影响CAL发生的因素进行卡方分析和多因素Logistic回归分析。【结果】①诊断典型KD61例(84.7%),非典型KD(AKD)11例(15.3%)。发病年龄6月至13.1岁(中位数2.73岁),5岁以下发病占87.5%。66例行超声检查,发现冠脉损害32例(48.5%)。②卡方分析显示C反应蛋白(CRP)与CAL的发生密切相关(P〈0.05);多因素Logistic回归分析显示CRP、是否使用静脉注入免疫球蛋白(IVIG)、IVIG使用时间、IVIG使用剂量与KD合并CAL显著独立相关(P〈0.05)。【结论】CRP增高、未使用IVIG或IVIG使用过晚、剂量小为KD合并CAL的危险因素。
[Objective]To describe the epidemiological and clinical characteristics of Kawasaki Disease(KD) and to investigate the risk factors of children with coronary artery lesion(CAL) secondary to KD. [Methods] The clinical data of 72 hospitalized children with KD were analyzed retrospectively. All cases with or without CAL were analyzed with Chi square test and multivariate logistic regression. [Results] Sixty one cases (84.7%) were diagnosed as typical KD and 11 cases (15.3%) were diagnosed as atypical KD. The onset age ranged from 6 months to 13.1 years old (median 2.73 years old). Sixty three cases (87.5% ) occurred among children aged below 5 years. Sixty six cases accepted echocardiograph examination, and CAL was found in 32 cases(48. 5% ). C-reactive protein (CRP) was closely associated with CAL secondary to KD( P 〈0.05). Multivariate Logistic regression analysis indicated that elevated CRP, the usage of intravenous immunoglobulin (IVIG), the time and dose of IVIG treatment were independently correlated with CAL secondary to KD. [Conclusion] Elevated CRP, the usage of IVIG, the time and dose of IVIG treatment are the risk factors of CAL in children with KD.
出处
《医学临床研究》
CAS
2009年第12期2303-2305,共3页
Journal of Clinical Research