肝病患者血清胆碱酯酶活性测定及其临床价值

The Determination of Serum Cholinesterase Activity of Hepatopathsand clinical Significance

检测112例各型肝病患者及100例正常人血清胆碱酯酶（ChE）活性。结果表明：各型肝病患者血清ChE活性均显著低于正常对照组（P＜0．01）；血清ChE活性与白蛋白呈显著正相关，与谷丙转氨酶（ALT）无明显相关。对28例急性肝炎治疗前与恢复期的ChE活性进行比较，有显著性差异（P＜0．01）。结果表明：ChE活性是反映肝细胞损害的敏感指标，对估计肝脏的储备功能，了解病情变化及预后判定具有一定的临床价值。提示我国可能存在家族性低胆碱酯酶血症患者。

Objective: Reports the determination of serum cholinesterase (ChE) activity of 112 hepatopaths and 100 normal subjects of a control group. The results showed that the serum ChE activity of the hepatopaths of the various types was noticeably lower than that of the control group (P < 0.01 ). The relationship of the serum ChE activity indirect proportion to albumin was marked but no enough to ALT.The serum ChE activity of 28 cases in the pretreatment Period showed an obvious difference from that in the convalescent period (P < 0.01 ). This study Shows that ChE activity is a sensitive indication of hepatic impairment, and it is the refore of considerable clinical significance in the evaluation of the hepatic reserve functions and in the understanding and prognosis of hepatopathy. The study the suggests the possible existence of cases with familiar hypocholinesteremia in China.