3Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 2002; 4:487-494.
4Takano S, Kanai F, Jazag A, et al. Smad4 is essential for down-regulation of E-cadherin induced by TGF-β in pancreatic cancer cell line PANC-1. JBiochem 2007; 141:345-351.
5Kaimori A, Potter J, Kaimori JY, et al. Transforming growth factor-β1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem 2007; 282:22089-22101.
6Bardeesy N, Cheng KH, Berger JH, et al. Smad4 is dispensable for normal pancreas development yet critical in progres- sion and tumor biology of pancreas cancer. Genes Dev 2006; 20:3130-3146.
7Desgrosellier JS, Mundell NA, McDonnell MA, Moses HL, Barnett JV. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev Biol 2005; 280:201-210.
8Armstrong E J, Bischoff J. Heart valve development: endothelial cell signaling and differentiation. Circ Res 2004; 95:459- 470.
9Saika S, Ikeda K, Yamanaka O, et al. Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelialmesenchymal transition of lens epithelium in mice. Lab Invest 2004; 84:1259-1270.
10Xu GP, Li QQ, Cao XX, et al. The fffect of TGF-β1 and SMAD7 gene transfer on the phenotypic changes of rat al- veolar epithelial cells. Cell Mol Biol Lett 2007; 12:457-472.