血清对氧磷酶活性联合丙二醛在子痫前期发病中的意义

The significance of the changes of paraoxonase activities and malondialdehyde content in preeclampsia

目的探讨子痫前期(PE)孕妇血清中对氧磷酶活性(PON)、丙二醛(MDA)含量与PE发病及病情轻重程度的相关性。方法选择PE患者60例作为试验组,另取健康晚孕期女性40例作为对照组。检测和观察PE孕妇血清中PON活性、MDA含量变化。结果试验组孕妇血清中PON活性(99±33)kU/L显著低于对照组(140±33)kU/L(P<0.01),其中重度PE组PON活性(82±30)kU/L较轻度PE组(116±27)kU/L明显降低(P<0.01),轻度PE组亦低于对照组(P<0.05)。试验组孕妇血清中MDA含量(6.1±1.6)nmol/L显著高于对照组(4.4±0.9)nmol/L(P<0.01),其中重度PE组MDA含量(7.1±1.5)nmol/L较轻度PE组(5.2±1.0)nmol/L明显升高(P<0.01),轻度PE组亦高于对照组(P<0.05)。结论PON活性、MDA含量高低与PE发病及病情轻重程度有关。

Objective To investigate the correlation between paraoxonase（PON）activities as well as malondialdehyde（MDA）content and the pathogenesis and the degree of severity of preeclampsia（PE）.Methods 60 patients with PE were enrolled as trial group,and 40 healthy pregnant women at late duration of pregnancy were in control group.The PON activity and MDA content in serum were detected.Results The serum PON activity in trial group[（99±33）kU/L] was significantly lower than that in control group [（140±33）kU/L,（P〈0.01）].As compared with those of mild preeclampsia group[（116±27）kU/L],the serum PON activity in severe preeclampsia group[（82±30）kU/L] was significantly lower（P〈0.01）.The serum PON activity in mild preeclampsia group was also significantly lower than that in control group（P〈0.05）.The serum MDA levels in trial group[（6.1±1.6）nmol/L] were significantly higher than those in control group[（4.4±0.9）nmol/L],（P0.01）.As compared with those in mild preeclampsia group[（5.2±1.0）nmol/L],the serum MDA levels in severe preeclampsia group[（7.1±1.5）nmol/L] were significantly higher（P〈0.01）.The serum MDA levels in mild preeclampsia group were also significantly higher than those in control group（P〈0.05）.Conclusion The abnormality of the PON activity and MDA levels in patients with preeclampsia is related to the pathogenesis and to the degree of severity of preeclampsia.