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糖皮质激素、来氟米特、霉酚酸酯对T淋巴细胞亚群及细胞因子的影响 被引量：2

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摘要 糖皮质激素（Glucocorticoid，GC）作为免疫抑制药物用于临床的历史已久，而来氟米特（Leflunomide，LEF，爱若华）、霉酚酸酯（Mycophenolatemofetil，MMF，骁悉）属于新型免疫抑制药。本文就上述3种免疫抑制药对T淋巴细胞亚群及细胞因子的影响综述如下。
作者 孙特 王宝仁
机构地区 武警辽宁总队大连医院肾内科
出处 《武警医学》 CAS 2009年第12期1129-1132,共4页 Medical Journal of the Chinese People's Armed Police Force
关键词 糖皮质激素 来氟米特 霉酚酸酯 T淋巴细胞亚群 细胞因子
分类号 R979.5 [医药卫生—药品]
  • 相关文献

参考文献25

  • 1Chen X, Murakami T, Oppenheim JJ et al. Differential response of routine CD4^+ CD25^+ and CD4^+ CD25^- T cells to dexamethasone - induced cell death [ J 1. Eur J Immunol, 2004, 34 (3) :859.
  • 2Chung IY, Dong HF, Zhang X et al. Effects of IL - 7 and dexamethasone: induction of CD25, the high affinity IL-2 receptor, on human CD4^+ cells [ J ]. Cell Immunol, 2004, 232 ( 1 - 2) :57.
  • 3李霞,李殿俊,富东旭.免疫抑制剂对小鼠胸腺及外周血、脾脏T淋巴细胞亚群的影响[J].哈尔滨医科大学学报,2005,39(4):325-326. 被引量：9
  • 4Wu TH, Tsai CY, Yang WC. Excessive expression of the tumor necrosis factor- alpha gene in the kidneys of patients with membranous glomerulonephritis [ J ]. Zhonghua Yi Xue Za Zhi (Taipei), 1998,61(9) :524.
  • 5Seldon PM, Stevens DA, Adcock IM et al. Albuterol does not antagonize the inhibitory effect of dexamethasone on monocyte cytokine release[J]. Am J Respir Crit Care Med, 1998, 157(3): 803.
  • 6龚德华,王庆文.糖皮质激素作用机制的新进展[J].肾脏病与透析肾移植杂志,2000,9(1):62-64. 被引量：23
  • 7苏定雷,季晓辉.免疫抑制剂治疗系统性红斑狼疮作用机制的研究进展[J].国外医学（免疫学分册）,2004,27(3):133-136. 被引量：4
  • 8陆福明,李铭新.激素与免疫抑制剂在老年肾病中的应用[J].老年医学与保健,2006,12(2):72-74. 被引量：4
  • 9Dimitrova P, Skapenko A, Herrmann ML et al. Restriction of de novo pyrimidine biosynthesis inhibits Thl cell activation and promotes Th2 cell differentiation [ J ]. J Immunol, 2002,169 (6) : 3392.
  • 10Li WD, Ran GX, Teng HL et al. Dynamic effects of leflunomide on IL - 1, IL - 6, and TNF - alpha activity produced from peritoneal macrophages in adjuvant arthritis [ J]. Acta Pharmacol Sin, 2002,23(8) :752.

二级参考文献116

  • 1Waller EK, Lynn MJ, Boyer M, et al. Survial after allogeneic bone marrow transplantation (BMT) is predicted by the number of transplanted donor CD34+ cells and donor dendritic cell progenitors (DCPs). Blood,1998;92(suppl1):2041
  • 2Mehling A, Grabbe S, Voskort M, et al. Mycophenolate mofetil imparis the maturation and function of murine dendritic cells. J Immunol,2000;165:2374-2381
  • 3Simmons WD, Rayhill SC, Sollinger HW. Preliminary risk-benefit assessment of mycophenolate mofetil in transplant rejection. Drug Saf,1997;17:75-92
  • 4Krenger W, Cooke KR, Crawford JM, et al. Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host disease. Transplantation,1996;62:1278-1285
  • 5Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature,1998;392:245-252
  • 6Inaba K, Inaba M, Romani N, et al. Generation of large numbers of dendritic cells from bone marrow culture supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med,1992;176:1693-1702
  • 7Shlomchid WD, Couzens MS, Tang CB, et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells,Science,1999;285:412-415
  • 8Judge TA, Tang A, Turka LA. Immunosuppression through blockade of CD28: B7-mediated costimulatory signals. Immunol Res,1996;15:38-49
  • 9Ferrara JL, Cooke KR, Pan L, et al. The immunopathophysiology of acute graft-versus-host-disease. Stem Ceils,1996;14:473-489
  • 10Heufler C, Koch F, Stanzl U, et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-γ production by T helper 1 cells. Eur J Immunol,1996;26:659-668

共引文献85

同被引文献38

  • 1史燕军,贾瑞鹏.非糖皮质激素免疫抑制方案在肾移植中的研究进展[J].国际泌尿系统杂志,2006,26(1):76-79. 被引量：2
  • 2Bergmann T K,Barraclough K A,Lee K J,et al.Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation[J].Clin Pharmacokinet,2012,51(11):711-741.
  • 3Czock D,Keller F,Maximilian F,et al.Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids[J].Clin Pharmacokinet 2005,44(1):61-98.
  • 4Jeng S,Chanchairujira T,Jusko W,et al.Prednisone metabolism in recipients of kidney or liver transplants and in lung recipients receiving ketoconazole[J].Transplantation,2003,75(6):792-795.
  • 5Coutinho A E,Chapman K E.The anti-inflammatory and immunosuppressive effects of glucocorticoids,recent developments and mechanistic insights[J].Molecular Cellular Endocrinol,2011,335(1):2-13.
  • 6Wieland E,Olbricht C J,Süsal C,et al.Biomarkers as a tool for management of immunosuppression in transplant patients[J].Ther Drug Monit,2010,32(5):560-572.
  • 7Atalar K,Afzali B,Lord G,et al.Relative roles of Th1 and Th17effector cells in allograft rejection[J].Curr Opin Organ Transplant,2009,14(1):23-29.
  • 8Millán O,Rafael-Valdivia L,TorrademéE,et al.Intracellular IFN-c and IL-2 expression monitoring as surrogate markers of the risk of acute rejection and personal drug response in de novo liver transplant recipients[J].Cytokine,2013,61(2):556-564.
  • 9Gras J,Wieers G,Vaerman J L,et al.Early immunological monitoring after pediatric liver transplantation:cytokine immune deviation and graft acceptance in 40 recipients[J].Liver Transpl,2007,13(3):426-433.
  • 10Newton R.Molecular mechanisms of glucocorticoid action:what is important?[J].Thorax,2000,55(7):603-613.

引证文献2

二级引证文献8

武警医学
2009年 第12期

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