多发性硬化患者白细胞介素6水平及临床意义

The levels of interleukin6 in patients with multiple sclerosis and their clinical significance

目的探讨白细胞介素６（ＩＬ６）在多发性硬化（ＭＳ）发病中的作用。方法以生物学方法检测３７例ＭＳ患者血清及脑脊液（ＣＳＦ）中ＩＬ６含量。结果ＭＳ患者血清及脑脊液中ＩＬ６含量分别为７２６７±５２４６；１７５０±５２１Ｕ／ｍｌ而非炎症性神经病（ＮＩＮＤ）组分别为１９７４±１３８１和５５６±２２５Ｕ／ｍｌ，正常对照（ＮＣ）组血清ＩＬ６含量为６３３±１０３９Ｕ／ｍｌ，ＭＳ患者血清及脑脊液ＩＬ６水平均明显高于对照组（Ｐ＜００１），但ＭＳ患者血清与ＣＳＦＩＬ６水平不呈线性相关，血清ＩＬ６水平随病情稳定而下降。

Objective To investigate the role of interleukin6 (IL6) in multiple sclerosis (MS).Methods The interleukin6 levels in serum and cerebrospinal fluid (CSF) from 37 patients with MS were measured by using a sensitive bioassay.Results The IL6 in serum and CSF from patients with MS was 72.67±52.46, 17.50±5.72 U/ml respectively and from those with NIND 19.74±13.81 U/ml and 5.56±2.25 U/ml respectively and from those with NC 6.33±10.39 U/ml in serum. The IL6 levels of serum and CSF in patients with MS were significantly higher than in controls (P<0.01), but no relationship was observed in IL6 levels between serum and CSF. The serum IL6 levels were high at onset and fell down with stabilizing of patient′s condition.Conclusion IL6 participates in immunopathological process of MS.