摘要
目的探讨白细胞介素6(IL6)在多发性硬化(MS)发病中的作用。方法以生物学方法检测37例MS患者血清及脑脊液(CSF)中IL6含量。结果MS患者血清及脑脊液中IL6含量分别为7267±5246;1750±521U/ml而非炎症性神经病(NIND)组分别为1974±1381和556±225U/ml,正常对照(NC)组血清IL6含量为633±1039U/ml,MS患者血清及脑脊液IL6水平均明显高于对照组(P<001),但MS患者血清与CSFIL6水平不呈线性相关,血清IL6水平随病情稳定而下降。
Objective To investigate the role of interleukin6 (IL6) in multiple sclerosis (MS).Methods The interleukin6 levels in serum and cerebrospinal fluid (CSF) from 37 patients with MS were measured by using a sensitive bioassay.Results The IL6 in serum and CSF from patients with MS was 72.67±52.46, 17.50±5.72 U/ml respectively and from those with NIND 19.74±13.81 U/ml and 5.56±2.25 U/ml respectively and from those with NC 6.33±10.39 U/ml in serum. The IL6 levels of serum and CSF in patients with MS were significantly higher than in controls (P<0.01), but no relationship was observed in IL6 levels between serum and CSF. The serum IL6 levels were high at onset and fell down with stabilizing of patient′s condition.Conclusion IL6 participates in immunopathological process of MS.