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具有抗癌活性天然大环内酯的研究进展

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摘要 目的从结构和生物活性等方面,对近年来发现的具有抗癌活性天然大环内酯进行综述。方法通过对国内外文献的分析、整理和归纳,较为全面的介绍了具有抗癌活性天然大环内酯的研究现状。结果与结论具有抗癌活性天然大环内酯结构独特,作用机制新颖,不仅可以提供新结构类型的抗肿瘤先导化合物,而且为发现新的作用靶点提供了依据。
机构地区 山东大学药学院
出处 《中国药学杂志》 CAS CSCD 北大核心 2009年第24期1841-1846,共6页 Chinese Pharmaceutical Journal
基金 国家自然科学基金资助项目(20872081) 山东省自然基金资助项目(Y2006c31) 山东省科技攻关项目(2005GG3202098)
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  • 1NEWMAN D J, GRAGG G M. Natural products as sources of new drugs over the last 25 years [J]. Nat Prod, 2007, 70(3): 461-477.
  • 2KORTMANSKY J, SCHWARTZ G K. Bryostatin-1: A novel PKC inhibitor in clinical development [J]. Cancer Invest, 2003, 21(6): 924-936.
  • 3LI Y, MOHAMMAD R M, AL-KATIB A, et al. Bryostatin 1 (bryol)-indueed monocytic differentiation in THP-1 human leukemia cells is associated with enhanced c-fyn tyrosine kinasc and M-CSF receptors [J]. Leukemia Res, 1997, 21(5): 391-397.
  • 4KUZIRIAN A M, EPSTEIN H T, GAGLIARDI C J, et al. Bryostatin enhancement of memory in Hermissenda [J]. Biol Bull, 2006, 210(3): 201-214.
  • 5NISHIMURA S, MATSUNAGA S, YOSHIDA M, et al. 13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit [J]. Bioorg Med Chem, 2005, 13(2): 449-454.
  • 6MERAGELMAN T L, WILLIS R H, WOLDEMICHAEL G M, et al. Candidaspongiolides, distinctive analogues of Tedanolide from sponges of the genus candidaspongia [J]. Nat Prod, 2007, 70(7): 1133-1138.
  • 7CHEVALLIER C, BUGNI T S, FENG X, et al. Tedanolide C: A potent new 18-membered-ring cytotoxic macrolide isolated from the papua new guinea marine sponge Irc'inia sp. [J]. J Org Chem, 2006, 71(6): 2510-2513.
  • 8CANTRELL C L, GUSTAFSON K R, CECERE M R, et al. Chondropsins A and B: Novel tumor cell growth-inhibitory macrolide lactams from the marine sponge chondropsis sp. [J]. JAm Chem Soc, 2000, 122(37): 8825-8829.
  • 9RASHID M A, GUSTAFSON K R, BOYD M R. New chondropsin macrolide laetams from marine sponges in the genus lrcinia [J]. Tetrahedron Lett, 2001, 42(9): 1623-1626.
  • 10TAKEMOTO D, TAKEKAWA Y, VAN SOEST R W M, et al. Poecillastrin D: A new cytotoxin of the chondropsin class from marine sponge Jaspis serpentina [J]. Biosci Biotechnol Biochem, 2007, 71(11): 2697-2700.

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