肾内动脉阻力指数及尿白蛋白指数对Ⅱ型糖尿病早期肾病的诊断意义

THE EV ALUATION OF INTRARENAL ARTERIAL RESISTIVE INDEX AND URINE ALBUMIN-TO-CREATININE RATIO IN DIAGNOSIS OF EARLY NEPHROPATHY OF DLABETES MELLITUS Ⅱ

目的观察Ⅱ型糖尿病早期肾病时肾内动脉阻力指数的变化规律以及其对诊断的意义。方法利用彩色多普勒超声检测了２０名早期肾病的Ⅱ型糖尿病患者肾内动脉阻力指数，与２０名非早期肾病的Ⅱ型糖尿病患者作比较。结果发现早期肾病的病人肾内动脉阻力指数明显升高，超过正常上限者达８５％。结论肾内动脉阻力指数升高可以提示早期糖尿病肾病的诊断。如同时以肾内动脉阻力指数结合尿白蛋白指数来诊断早期糖尿病肾病，结果诊断敏感度达９５％，特异度为８５％。

PURPOSE To observe the variability of intrarenal resistive index(RI) and its diagnostic evaluation. METHODS By means of Color Doppler technics, intrarenal arterial RI was measured in 20 cases of diabetes mellitus Ⅱ patients with early diabetic nephropathy (DN), and the results were compared with those from 20 diabetes mellitus Ⅱ patients without early DN. RESULTS It was found that intrarenal arteral RI in patients with early DN were markedly increased, the number of patients whose intrarenal arterial RI exceeded normal upper limit reached 85%. CONCLUSIONS The increase of intrarenal arterial RI is useful for the diagnosis of early DN. If intrarenal arterial RI and urine albumin to creatinine ratio (ACR) is combined to diagnose early DN, the sensitivity and specificity of diagnosis will be 95% and 85% respectively.