肝癌切除合并脾切除治疗伴有脾功能亢进肝癌的疗效观察

Observation of efficacy of liver cancer resection and splenectomy in treatment of the patients with hepatocellular cancer and hypersplenism

目的探讨肝癌合并脾功能亢进患者肝癌切除合并脾脏切除的临床意义。方法回顾分析2004年3月至2006年1月我科收治的12例患者,分析手术前后肝功能和血小板、白细胞变化情况。结果术后3d患者白细胞由术前的(3.2±1.7)×109/L升至(13.5±5.3)×109/L,血小板由(52.6±23.7)×109/L升至(245.3±94.6)×109/L,脾功能亢进消失,肝脏功能术后1周也基本恢复至术前水平。结论肝癌切除合并脾脏切除是治疗肝癌合并脾功能亢进患者的有效方法。

Objective To investigate the clinical efficacy of liver cancer resection combined with splenectomy in treatment of the hepatocellular cancer patients with hypersplenism. Method The data of liver function, changes of platelet count and white blood cell count in 15 hepatocellular cancer patients with hypersplenism were analyzed retrospectively. Results Three days after operation, the white blood cell count increased from （3.2 ± 1.7） ×10^9/L to （ 13. 5 ±5.3） ×10^9/L, the platelet count increased from （52. 6 ± 23.7） ×10^9/L to （245.3 ±94. 6） ×10^9/L（P 〈0.01 ）. The major parameters of the liver function recov- ered to their preoperational values within 1 week. Conclusion Liver cancer resection combined with splenectomy was effective for treatment of the hepatocellular cancer patients with hypersplenism.