有约束模拟退火法优化3D立体定向放射治疗计划

Application of Constrained Simulated Annealing to 3D Stereotactic Radiothrapy Treatment Planning

采用线性规划法与改进的有约束模拟退火法相结合，优化Ｘ刀立体定向放射治疗计划。第一阶段的线性规划法可以缩小解空间，以利于第二阶段的有约束模拟退火法采用较小的权值修正粒度。实验研究表明：经过两个阶段优化，我们达到了放射治疗计划优化的目的。

In this paper,linear programming and constrained simulated annealing are combined to optimize X knife stereotactic radiothrapy treatment planning.In the first phase,linear programming reduces the resolution space,which is favourable to the adoption of little granularity in the second phase.Our experiment demonstrates that after the two phase optimization,we attain the expected result.