摘要
目的研究甲地孕酮防治肿瘤化疗中白细胞减少的疗效和对患者生活质量的影响。方法100例肿瘤患者被随机分为研究组(50例)和对照组(50例),对照组:地榆升白片4片/次,3次/d,全程口服。研究组:地榆升白片4片/次,3次/d,全程口服;甲地孕酮160mg,1次/d,连用10d,自化疗第1天早晨口服,3周为1周期,两周期后评价患者白细胞减少的程度及生活质量。结果研究组和对照组白细胞减少发生率分别为50.0%和72.0%,差异有显著性(P<0.05)。Ⅲ度以上减少发生率分别为12.0%和26.0%(P>0.05)。食欲降低发生率分别为58.0%和90.0%(P<0.01),Karnofsky未下降比率分别为90.0%和52.0%(P<0.01),体重增加比率分别为86.0%和38.0%(P<0.01)。两组疼痛减轻比率分别为72.0%和56.0%(P>0.05)。结论在肿瘤化疗中,甲地孕酮能够明显缓解肿瘤化疗中白细胞减少,同时明显提高患者生活质量。
Objective To study the efficacy of megestrol acetate （MA） in the prevention of leucopenia due to chemotherapy and its influence on QOL. Methods 100 patients were randomized to study group （50 cases） and control group （50 cases）. The control group took DI YU SHENG BAI PIAN 4 tablets, tid, in the whole cycle. The study group took DI YU SHENG BAI PIAN 4 tablets, tid, in the whole cycle and MA 160 mg qd for 10 days from the morning of the dayl of chemotherapy, three weeks constituded one cycle. The efficacy and QOL were evaluated after two cycles. Results The rate of leucopenia （ I -IV ） in study group and control group was respectively 50. 0% and 72. 0%, with significant difference（P 〈0. 05）. The rate of leucopenia （Ⅲ-Ⅳ） was respectively 12. 0% and 26. 0% （P 〉0. 05） ; the rate of anorexia was respectively 58.0% and 90. 0% （P 〈 0. 01 ） ; the rate of no derease in KPS was respectively 90. 0% and 52. 0% （ P 〈 0. 01 ）, the rate of gaining weight was respectively 86. 0% and 38.0% （ P 〈 0. 01 ）, the rate of pain relief was respectively 72.0% and 56. 0% （P 〉 0. 05）. Conclusion Megestrol acetate can alleviate the leucopenia due to chemotherapy significantly, and improve the QOL.
出处
《中国肿瘤临床与康复》
2009年第6期573-575,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
