脉冲式微透析法葡萄糖传感器系统——部分体外实验

Pulsatile Microdialysis Method with Glucose Sensor System

为构建一小型的皮下组织葡萄糖传感器系统，简化其葡萄糖监测前后的校正过程，改进其温度特性，本研究采用了脉冲式微泵和微透析技术，在５－５ｍＭ及１０ｍＭＧ．Ｓ中对这个葡萄传感器系统进行了葡萄糖恢复的实验。在２０４０℃的范围，每５℃为一阶梯进行渐增渐减温度实验。结果显示葡萄糖恢复达（９７±２）％；传感器输出电流虽随温度的增高而增加，但温度系数仅３－４％。本系统具有体积小，校正简便的特点，能克服温度的干扰而适用于发热的糖尿病患者血糖的监测。

To develop a miniature subcutaneous glucose sensor system, to simplify calibration procedure before or after glucose monitor, and to improve its temperature characteristic, a pulsatile micropump and the microdialysis technique were used. The experiments of glucose recovery in 5.5mM and 10mM G.S. and the temperature experiment from 20℃ to 40℃ were conducted. The results showed that glucose recovery was (97±2)%, the current values of glucose sensor varied with temperature, but the temperature parameter was only 3.4%. These indicate that the glucose sensor system is miniature and the calibration procedure is simple. Because of its modified temperature characterisic, it is useful to monitor the blood glucose of feverish diabetics.