外源性生长抑素对脑出血患者血清炎性介质表达的影响研究

Exogenous Somatostatin on Serum Inflammatory Mediator Expression in Patients with Cerebral Hemorrhage

目的观察外源性生长抑素对脑出血患者血清炎性介质表达的影响,探讨其在脑出血患者发挥拮抗炎性损伤的作用及机制。方法60例脑出血患者随机分为治疗组及干预组,患者治疗前检测血清生长抑素(SS)及TNF-α、IL-6及IL-10表达水平,并与30例健康人对照组比较,治疗组给予生长抑素2.5μg/h,1周后观察治疗组及干预组TNF-α、IL-6及IL-10表达水平差异。结果治疗前对照组血清生长抑素、TNF-α、IL-6及IL-10表达水平低于治疗组及干预组,治疗组及干预组血清TNF-α、IL-6及IL-10表达水平无差异,治疗1周后,治疗组血清TNF-α、IL-6水平高于干预组,IL-10表达水平低于干预组。结论脑出血患者生长抑素及炎症介质高表达,外源性生长抑素能够抑制炎性介质的过度释放,减轻炎症反应。

Objective To observe the effect of exogenous somatostatinon serum inflammatory mediator expression in patients with cerebral hemorrhage and its antagonistic role and mechanism of inflammatory injury in cerebral hemorrhage. Methods Sixty patients with cerebral hemorrhage were randomly divided into therapeutic group and intervention group,and 30 healthy adults were served as control group. Before treatment,the somatostatin level,tumor necrosis factor α （TNF-α）,interleukin 6（IL-6） and interleukinlO（IL-10） were detected,the therapeutic group was given somatostatin 2.5μg/h,and the levels of TNF-α ,IL-6 and IL-10 were compared between the therapeutic group and the intervention group after one week treatment. Results Before treatment,the levels of TNF-α, IL-6 and IL-10 were lower in the control group than those in the therapeutic group and the intervention group,there was no difference in the levels of somatostatin,TNF-α ,IL-6 and IL-10 between the therapeutic group and the intervention group,and after one week treatment,the levels of TNF-α and IL-6 were higher and the IL-10 level was lower in the therapeutic group compared with the intervention group. Conclusion Exogenous somatostatin can inhibit excessive release of inflammatory mediators.