肾积水患者尿内皮素与内皮衍化舒张因子变化关系的探讨

Urinary excretion of endothelin and endothelium-derived relaxing factor in hydronephrosis patients

为探讨肾积水患者尿内皮素（ET）与内皮行化舒张因子（EDRF）变化的关系，对40例单侧输尿管梗阻性肾积水患者ET与EDRF的水平进行检测，并与16例正常人作对照。发现在梗阻性肾积水患者肾盂尿中ET的水平较对照组明显升高（P＜0．01），EDRF的水平较对照组明显降低（P＜0．01），肾积水程度越重，上述变化越明显。提示在梗阻性肾积水中，梗阻肾合成的过量ET没有被定量的EDRF所拮抗，这可能是梗阻肾发生缺血性萎缩的一个原因。

The standards of urinary excretion of endothelin (ET),and endothelium derived relaxing factor (EDRF) were measured in 40 patients with unilateral ureteric obstruetive hy dronephrosis and compared it with that of 16 normal subjects. It was found that urinary ET excretion in hydronephrosis patients was significantly mcreased than that of normal subjects (P<0.01), urinary EDRF excretion was significantly decveased than that of normal subjects (P <0.01 ),the more severe hydronephrosis,the higher the change is. It was suggested that the excess of ET production in hydronephrosis patients was not counter-balanced by adequate EDRP biosynthesis,which might be one cause contributed to ischemic renal atrophy.