摘要
利用异硫氰酸荧光素标记的纤维蛋白建立大白鼠肺血栓模型,将一种纤溶促进化合物MTP从尾静脉注射于肺血栓大白鼠,观察肺组织切片和检测血浆中异硫氰酸荧光素-纤维蛋白的降解状况。发现化合物MTP有促进实验动物肺血栓的溶解作用,推测化合物MTP的添加提高了纤溶因子的纤溶活性。
The effect of compound MTP on induced clotlysis and its possible mechanism were investigated on the experimental model of pulmonary thrombosis in rat with fibrin labeled with FITC. The histological specimens of rat lung tissue were prepared and the degradation of FITC-labeled fibrin was analyzed by SDS-PAGE. The results showed that MTP was able to enhance fibrinolysis in vivo. It was speculated that compound MTP could enhance intrinsic activity of prourokinase as a plasminogen activator in a rat pulmonary embolism model.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2009年第23期410-414,共5页
Food Science
基金
上海市科委浦江人才计划项目(07pj14077)
上海市教委重点研究项目(2500060412)
