2005-2008年嗜麦芽寡养单胞菌的耐药性监测研究

Research on Surveillance of Drug Resistance of Stenotrophomonas maltophilia from 2005 to 2008

目的了解2005-2008年嗜麦芽寡养单胞菌的临床分离情况及耐药现状,为临床合理用药提供参考。方法应用VITEK-32全自动微生物分析系统对临床分离菌株进行菌种鉴定和药物敏感试验,部分抗菌药物采用K-B纸片扩散法。结果2005年1月-2008年12月共分离出295株嗜麦芽寡养单胞菌;标本来源以痰液标本最多,科室分布以重症监护病房为主(50.17%);药敏结果显示,大多数药物的耐药性都较强,耐药率最低的是左氧氟沙星,其次为复方新诺明和环丙沙星。结论嗜麦芽寡养单胞菌对常用抗菌药物表现为严重耐药和多药耐药,应引起临床高度重视,临床抗感染治疗应根据药敏试验结果选用敏感药物。

OBJECTIVE To investigate the isolation rate and drug-resistance of Stenotrophomonas maltophilia so as to provide evidence for clinical rational use of drugs.METHODS The strains of S.maltophilia isolated from clinical specimens were identified and tested on drug sensitivity by the VITEK-32 system.Parts of the isolates were tested by disc diffusion method.RESULTS A total of 295 strains were identified during from Jan 2005 to Dec 2008.The most of the were isolated from sputum in clinical samples,and ICU was the main distribution department.The result showed that S.maltophilia had higher resistance rate to most drugs.Levofloxacin had the lowest resistance rate followed by trimethoprim-sulfamethoxazole and ciprofloxacin.CONCLUSIONS S.maltophilia has serious resistance rate to common antimicrobial agent showing mult-drug resistance.We should pay more attention to the status,and rationally choose antibiotics according to the drug susceptibility.