体质指数增加对蛋白尿检出率及估计肾小球滤过率降低的影响

The Effects of Increased Body Mass Index on the Prevalence of Proteinuria and Decreased Estimated Glomerular Filtration Rate

目的探讨体质指数(BMI)增加对合肥市体检人群蛋白尿检出率及估计肾小球滤过率降低的影响。方法回顾性分析2005年1月至2007年12月在安徽省立医院体检中心大于20周岁、BMI≥18.5 kg/m^2人群的体检资料,分析BMI增加与蛋白尿检出率及估计肾小球滤过率(eGFR)降低之间的关系。结果 BMI正常组、超重组、肥胖组蛋白尿检出率分别为1.98%,3.07%和5.27%;eGFR中重度降低检出率分别为0.76%,1.19%和1.46%。Logistic回归分析发现,BMI增加是蛋白尿检出率增高的独立危险因素(OR=1.154,95%CI:1.039～1.282,P<0.01 。结论 BMI增加与合肥市体检人群蛋白尿检出率增高密切相关。

Objective To evaluate the relationship of increased body mass index （BMI） with the prevalence of proteinuria and decreased estimated glomerular filtration rate （eGFR） in adult population receiving body check from urban area of Hefei, Anhui. Methods A total of 32 393 subjects who were older than 20 years and received healthy examination in Health Center of Anhui Provincial Hospital from January 2005 to December 2007 were enrolled in this study. They were divided into groups of normal body weight（BMI 18.5 to 23.9 kg/m^2）, overweight（BMI 24 to 27.9kg/m^2） and obese（BMI ≥ 28 kg/m^2）. Results In participants with normal body weight, overweight, and obese, the prevalence of proteinuria was 1.98%, 3.07% and 5.27%, and the prevalence of moderately and severely reduced eGFR, defined as an eGFR〈60 ml/min/1.73 m^2, was 0.76%, 1.19%, and 1.46%, respectively. The logistic regression model showed that increased BMI was one of the independent risk factors for proteinuria, but not for moderately and severely reduced eGFR. Conclusions Increased body mass index is strongly associated with proteinuria in adult population receiving body check from urban area of Hefei, Anhui.