一次性使用静脉营养输液袋化学稳定性考察

Chemical Stability of Disposable Infusion Bag of Total Parenteral Nutrition

目的:考察一次性使用静脉营养输液袋的化学稳定性。方法:将0.9%氯化钠注射液放入一次性使用静脉营养输液袋中,分别于8℃和37℃放置不同时间(0、24、48、72h),以其为供试液,与空白对照液(0.9%氯化钠注射液放置于玻璃瓶)比较酸碱度、金属离子、不溶性微粒、氯化物、还原物质、紫外吸光度、环己酮溶出量的变化。结果:8℃时放置24h时各项指标稳定,37℃时随放置时间延长,与空白对照液比较,还原物质、环己酮溶出量增加;8℃与37℃比较,后者紫外吸光度增加。结论:一次性使用静脉营养输液袋注入注射液后应于8℃左右存放较宜,并应于24h内使用完毕。

OBJECTIVE： To study the chemical stability of disposable infusion bag of total parenteral nutrition. METHODS： 0.9% sodium chloride injection was infused into the disposable infusion bag of total parenteral nutrition and set at 8 ℃ or 37 ℃ for different duration （0, 24, 48, and 72 h） as sample solution. The sample solution was compared with blank control （0.9% sodium chloride injection contained in glass bottle） in respect of pH value, metal ion, indissoluble particle, chloride, reduction substance, UV absorbance and dissolution of cyclohexanone. RESULTS： Each index was stable when sample solution was set at 8℃ for 24 h. Reduction substance and dissolution of cyclohexanone increased when solution was set at 37 %; with time prolonged, as compared with blank control. At 37℃ UV absorbance is more than that at 8℃. CONCLUSION： It is suitable to set disposable infusion bag of total parenteral nutrition at 8℃ after infusing with injection and use up within 24 h.