摘要
钙增敏剂是一类新的强心药物,该类药物通过增加心肌收缩蛋白对Ca2+的敏感性来发挥强心作用,克服了传统强心药增加心肌耗氧量和引起细胞内钙超载等缺点,在治疗心衰、休克及心脏保护方面有良好的发展前景。文中综述了该类药物的分类、已上市药物及正在进行临床研究药物近年的研究进展。
Calcium sensitizers are inotropic drugs. They exert intropic effects by enhancing the sensitization of contractile proteins to calcium. Calcium sensitizers could avoid the disadvantages of traditional inotropic drugs that would increase the myocardial oxygen consumption and cause the intracellular calcium overload. These new inotropic drugs have good development prospect in the treatment of heart failure and shock,and in heart protection. This article summarized the advance in the research of these drugs.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2010年第1期28-32,共5页
Chinese Journal of New Drugs
关键词
钙增敏剂
心力衰竭
休克
心脏保护
calcium sensitizers
heart failure
shock
heart protection
