脂肪肝中医证候分类研究中多元统计方法的应用

Using the Methods of Multivariate Statistical Analysis to Study the syndrome Categorization of TCM

目的:为如何选用多元统计方法用于中医证候分类研究提供参考。方法:通过2次因子分析提取脂肪肝的基本证型,利用因子得分揭示基本证型的组合规律,结合聚类分析归纳出脂肪肝常见的复合证型。结果:脂肪肝的基本证型为肝肾不足、阴虚火旺、肝郁脾虚、脾虚、脾虚湿阻、湿热内蕴、血瘀、痰湿内阻;基本证型组合形式以1～4个多见,病机较简单时,脾虚湿阻型最常见,病机较复杂时,肝肾不足型最常见;有13.6%的患者表现为无症状型,5.8%的患者表现为不可分类型,其余患者被聚为五型,分别为脾虚痰瘀互结11.5%、肝肾阴虚18.5%、脾虚痰湿中阻32.0%、脾虚湿热内蕴10.2%和肝郁脾虚湿阻8.3%。结论:将因子分析和聚类分析等多种多元统计方法合理地结合应用,能对中医证候进行比较客观地分类。

Objective： To do references for reasonably use the methods of multivariate statistical analysis to study the syndrome categorization of TCM. Methods ： To extract the basic syndrome patterns of fatty liver with the method of twice factor analysis. To display the combination rule of the basic syndrome patterns with the method of factors score. To conclude the main syndrome patterns combined with the method of cluster analysis. Results. Insufficiency of liver and kidney, asthenic yin causing excessive pyrexia, liver - qi stagnation and spleen asthenia, splenic asthenia, splenic asthenia and dampness stagnation, interior accumulation of dampness - heat, blood stasis, interior stagnation of phlegm - dampness are the basic syndrome patterns of fatty liver. One to four basic syndrome patterns combined is common for fatty liver, the syndrome pattern of splenic asthenia and dampness stagnation is most frequent when its pathogenesis is simple, and the syndrome pattern of insufficiency of liver and kidney is most frequent when is compficated. 13.6% patients of the pattern of mild symptom and 5.8% patients belong to the pattern of non - categorization, other patients are divided into five groups： the pattern of splenic asthenia and coagulatetion of phlegm and stagnated blood 11.5%, yin asthenia of liver and kidney18.5%, splenic asthenia and retention of phlegmatic dampness 32.0%, splenic asthenia and interior accumulation of dampness -heatl0.2%, fiver-qi stagnation and spleen asthenia with dampness stasis 8.3%. Conclusion： Reasonably combined the methods of several multivariate statistical analyses, which ave factor analysis, cluster analysis and so on, objective categories of TCM syndrome could be carry out.