摘要
目的:探讨VEGFR2和c-Cbl在胃癌组织中的表达及其临床意义。方法:构建胃癌组织芯片,应用免疫组化的方法,检测两种蛋白的表达情况。结果:VEGFR2和c-Cbl在胃癌组织中的阳性表达率分别为85.5%和71.0%。VEGFR2蛋白表达与浸润深度、淋巴结转移及病理分期有关(P<0.05),而与性别、年龄、分化程度无关;c-Cbl蛋白表达与浸润深度及病理分期有关(P<0.05),而与性别、年龄、分化程度及淋巴结转移无关。VEGFR2与c-Cbl的表达强度呈正相关。结论:VEG-FR2和c-Cbl在胃癌中高表达;VEGFR2和c-Cbl蛋白的表达强度与胃癌的浸润深度及病理分期均呈正相关;VEGFR2与淋巴结转移呈正相关;VEGFR2与c-Cbl的表达强度亦呈正相关。
Objective：To investigate the expression and significance of VEGFR2 and c-Cbl in gastric carcinoma. Methods： The expressions of VEGFR2 and c-Cbl were detected by immunohistochemical method of SP. Results：The positive expression rates of VEGFR2 and c-Cbl were 85.5% ,71.0% in gastric carcinoma, respectively, which were both higher than those in normal tissues （ P 〈 0. 05 ）. The expression of VEGFR2 was positively correlated with depth of invasion and lymph node metastasis and TNM staging. The expression of c-Cbl was positively correlated with depth of invasion and TNM staging;there was a positive relationship between the ex- pression of VEGFR2 and c-Cbl. Conclusion：The expressions of VEGFR2 and c-Cbl are associated with some clinicopathologic features and prognosis in gastric carcinoma, indicating that those may be prognostic factors for gastric carcinoma.
出处
《临床肿瘤学杂志》
CAS
2009年第12期1087-1091,共5页
Chinese Clinical Oncology
