索拉非尼对晚期肾癌患者生活质量的影响

The effect of quality of life during treatment with sorafenib in metastatic renal cell carcinoma

目的:探讨索拉非尼对晚期肾癌患者生活质量的影响。方法:通过QLQ-C30量表对患者进行生活质量调查。结果:索拉非尼在治疗4周后与治疗前基线状态相比总体健康状况显著恶化,患者的角色、认知和社会功能显著降低。16周后,上述评分恢复。经济问题在治疗第4周与治疗前相比,评分显著升高,在第6、10、12周均存在,在第16周差异不显著。结论:索拉非尼对晚期肾癌患者生活质量的影响可能是负面的,暂时的,患者可以耐受。

Objective：To explore the effect of quality of life （QOL） during treatment with sorafenib in metastatic renal eell carcinoma（mRCC）. Methods：To investigate quality of life of the patients by QLQ-C30 questionnaire. Results：Compared with baseline status, global quality of health（QL） deteriorated significantly during the first 4 weeks of treatment by sorafenib. Patients experienced a reduction of their role, cognitive, and social function. Mter 16 weeks, QL and all functional scales recovered. Compared with baseline, financial problem increased significantly at weeks 4, 6, 10 and 12, after 16 weeks, financial problem was not significant. Conclusion：The effect of sorafenib for QOL in mRCC might be negative, transient, and the patients could be tolerant.