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自体髂骨移植修复犬牙槽突裂的实验研究 被引量：1

Autogenous Iliac Bone Grafts in the Restoration of Cleft Alveolus in Dogs
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摘要 目的:建立与临床牙槽突裂自体髂骨移植相似的Beagle犬动物模型,为临床唇腭裂序列治疗提供实验对象,适用于牙槽突裂植骨后的评价和相关研究。方法:7只24周龄Beagle犬,用外科手术方法制备上颌单侧牙槽突裂,再即刻植入自体髂骨建立动物模型,术后即刻及术后4、8、12周进行X线片检查和术后12周行组织学观察对其进行评价。1只犬仅制备牙槽突裂,不植骨作为空白对照。结果:所有实验组动物形成规则的牙槽突裂隙植骨区,裂隙两侧的牙齿未受损伤。术后12周,空白对照犬的牙槽突裂隙区无新骨形成。结论:该牙槽突裂即刻植骨动物模型与临床情况相似,重复性、稳定性好,可模拟临床进行相关实验研究。 Objective： The objective of this study was to establish a convenient and reliable animal model with cleft alveolus and repaired by autogenous iliae bone grafts. Methods： 8 Beagle dogs （24-week） were used as animal model Affilificial cleft alveolus were created through surgical approaches and autogenous iliac bone graft restored immediately in 7 dogs. The aheolus cleft was left in 1 dog, as blank control. The results were evaluated clinically, radiographically and bistopathologically. Results： X-ray examination and histological observation showed that in all experimental dogs, the cleft alveolus was restored regularly. X-ray examination showed the height of bone graft kept reducing. Bone resorption tended to stable after 8 weeks. But no bone regenesis was observed in alveolus cleft of the control. Conclusion： The surgically created animal model of alveolar cleft and bone autograft was reliable and stable.
作者 杨雁 储沨婷 张栋杰 钱玉芬
机构地区 昆明医学院附属口腔医院正畸科 上海交通大学医学院附属第九人民医院口腔正畸科上海市口腔医学重点实验室
出处 《口腔颌面外科杂志》 CAS 2009年第6期400-403,共4页 Journal of Oral and Maxillofacial Surgery
基金 上海市科学技术委员会资助项目(08DZ2271100)
关键词 牙槽突裂 即刻植骨 动物模型 BEAGLE犬 cleft alveolus bone graft animal model Beagle dog
分类号 R782.23 [医药卫生—口腔医学]
  • 相关文献

参考文献13

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二级参考文献19

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共引文献11

同被引文献13

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口腔颌面外科杂志
2009年 第6期

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