组蛋白甲基化与头颈部恶性肿瘤
Histone Methylation and Malignant Tumors of the Head and Neck
摘要
有研究表明,头颈部恶性肿瘤的发生率约为14/100000.约占全身恶性肿瘤的10%.患者的5年生存率为35%~60%。最近几年的研究发现,基因的表观遗传学改变在头颈部恶性肿瘤发生中起了一定的作用,并且日益受到人们的重视:其中,组蛋白乙酰化是一种重要的表观遗传学修饰方式.
出处
《口腔颌面外科杂志》
CAS
2009年第6期427-430,共4页
Journal of Oral and Maxillofacial Surgery
基金
国家自然科学基金资助项目(30672328
30572054)
上海市科学技术委员会资助项目(08DZ2271100)
上海市重点学科建设项目(S30206)
关键词
组蛋白甲基化
组蛋白去甲基化
头颈部
恶性肿瘤
histone methylation: histone demethylation
head and neck
malignant tumors
参考文献20
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共引文献4
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