2002—2005年上海市15～44岁青年人肺癌发病的时间趋势、现况及生存期分析

Lung cancer in young patients aged from 15 to 44 years:incidence trend,current status and survival analysis from 2002 to 2005

目的:分析2002—2005年上海市15～44岁青年人肺癌发病的时间趋势、现况及生存期。方法:收集上海市疾病预防控制中心"上海市肿瘤病例登记和管理系统"中的病例资料,应用年均变化百分率(annual percent change,APC)模型分析肺癌患者发病的时间趋势,应用SPSS 12.0软件和寿命表法计算各观察年份中患者的生存期和中位生存期,以Kaplan-Meier法和COX回归模型进行单因素和多因素分析。结果:2002—2005年上海市15～44岁人群新诊断肺癌病例共972例,占同期全人群肺癌病例的3.09%,男、女性发病比率为1.63∶1。15～44岁青年人肺腺癌的比率高于同期全人群肺腺癌的比率,而临床分期在2者间无明显差异。多因素分析结果显示,患者的性别、病理类型、临床分期和医院等级是青年人肺癌独立的预后因素。结论:上海市青年人肺癌的特征与全人群特征不同,有必要更深入地分析青年人肺癌的生物学特性。

Objective：To analyze the incidence trend,current status and survival period of young patients with lung cancer aged from 15 to 44 years in Shanghai between 2002 to 2005.Methods：All the data were collected from the database of registration and ma-nagement system of diagnosed cancer cases in Shanghai city organized by Shanghai Municipal Center for Disease Control Prevention.The incidence trend was analyzed by using APC（annual percent change）model.The survival period and median survival time were calculated by using SPSS 12.0 software and life table method.The univariate and multivariate analyses were analyzed by using Kaplan-Meier and COX regression model,respectively.Results：A total of 972 young patients with lung cancer who aged from 15 to 44 years were diagnosed in Shanghai between 2002 and 2005,accounting for 3.09% of the whole lung cancer population.The ratio of male and female patients was 1.63∶1.The percentage of adenocarcinoma in young patients was higher than that in whole lung cancer population at the same period,while the TNM stage was not significantly different between male and female young patients.Multivariate analysis demonstrated that gender,pathological classification and TNM stage were independent prognostic factors for young patients with lung cancer.Conclusion：The lung cancer had different characteristics in young patients compared with that in whole lung cancer population in Shanghai city.It was necessary to further investigate the biologic behavior of lung cancer in young patients.