婴幼儿朗格汉斯细胞组织细胞增生症自愈1例报告及文献复习

Self-healing Langerhans cell histiocytosis in a child:Case report and literature review

朗格汉斯细胞组织细胞增生症是朗格汉斯细胞及其前体细胞在全身或局部增生所致的一类疾病。3岁以内的婴幼儿多见急性播散型,病变累及全身多脏器多系统,预后较差,不经治疗的自然病程多在6个月以内。本文报告1例19个月龄朗格汉斯细胞组织细胞增生症病例,未经治疗而痊愈,随访9年余无复发。

Langerhans cell histiocytosis is an entity of Langerhans cell with its proto-cell proliferating locally or disseminatively.Children below 3 years old always present an acute disseminated type.The responsible cell involves in multiple systems and the viscera,so it often undergoes a poor prognosis.Without medical interference,the natural course of the disease may be within 6 months.But in this paper,a 19-month-old child was reported who was diagnosed Langerhans cell histiocytosis by biopsy and self-healed without treatment.After over 9 years of follow-up,no recurrence was found.