二氧化碳共聚物生物膜的物理结构性能表征

Physical Structure Characteristics of Carbon-dioxide-copolymer Biomembrane

目的:制备出二氧化碳共聚物生物膜并评价其各项物理结构性能。方法:配制医用二氧化碳共聚物溶液,采用盐析法制备出二氧化碳共聚物生物膜。测定其分子量,检测强度,评价其性能,扫描电镜观察其表面形态,检测接触角,评价其湿润性。结果:该方法可以制备出类似于人体骨膜样结构的多孔生物膜,即光滑面层较为光滑,多孔面层呈粗糙多孔状。孔隙率约77.4%。弹性模量38.1 MPa,断裂强度平均1.22 MPa。电镜观察显示其多孔面层呈多孔状,表面均为微米级孔所覆盖,孔径约200μm,平均孔径约120μm,孔孔之间相通;光滑面层光滑致密,微米级孔很少,表面很平整。接触角检测显示其有良好的湿润性,粗糙多孔面接触角平均85°,光滑面平均57°。结论:从其物理结构性能上看,该二氧化碳共聚物生物膜是一种十分理想的引导骨再生生物膜。

Objective： To prepare the carbon- dioxide- copolymer biomembrane and evaluate its physical structure characteristics. Methods： The solution of carbon dioxide copolymer was prepared and salt-leaching method was applied to form carbon-dioxide-copolymer biomembrane. Its molecular weight and intensity were measured. Surface was observed by SEM. Contact angle Was measured to evaluate its wetness. Results： Porous biomembrane sire liar to human being＇s outer periosteum could be gained through salt-leaching method. It can be described into two layers--the smooth layer and the porous layer. The porosity was 77.4% and Young＇s module was 38. tMPa with fracture intensity of 1.22MPa. The surface of the porous layer took on porous structure covered by micron pores en tirely. The pore size ranged inconsistently, with the aperture of the largest pore about 200μm, and the average aperture was about 120μm. The neighbouring pores could communicate with each other. The surface of the smooth layer presented smooth and compact structure and covered by few micron pores. The surface was very plane. The average values of contact angle were respectively 85 in the porous layer and 57 in the smooth layer, which indicated that the Wetness of carbon- dioxide- eopolymer biomembrane was good. Conclusion： According to the physical structure characteristics, carbon-dioxide-eopotymer biomembrane was an ideal biomembrane to guide bone regeneration.