凋亡相关基因蛋白bcl-xl和bak在肺鳞癌中的表达及意义

Expression and significance of bcl-xl and bak protein in lung squamous cell carcinomas

目的:探讨肺鳞状细胞癌中凋亡调控因子bcl-xl和bak蛋白的表达及其意义。方法:采用免疫组织化学技术检测50例肺鳞状细胞癌及20例正常肺组织中bcl-xl和bak蛋白的表达水平。结果:bcl-xl蛋白在肺鳞状细胞癌中表达水平高于正常肺组织(P<0.05)。bak表达水平低于正常肺组织(P<0.05)。bcl-xl和bak蛋白的表达水平在不同分化程度的肺癌之间差异有显著意义(P<0.05)。结论:肺鳞状细胞癌的发生、发展与bcl-xl和bak蛋白的异常表达有关,可能是细胞凋亡失衡的结果。

Objective：To investigate the expression and significance of bcl - xl and bak protein in lung squamous cell carcinomas. Methods ： Immunohistochemical technique was used to detect the expression of bcl - xl and bak protein in 40 cases of lung squamous cell carcinomas, 10 normal lung tissues. Results ： Expression of bcl - xl were observed in lung carcinomas, that was higher in lung carcinomas than in normal lung tissues （ P 〈 0.05 ）, and bak was lower in lung carcinomas than in normal lung tissues （ P 〈 0.05 ）. Significant differences were observed for bcl - xl and bak expression levels in different differentiated lung carcinoma （ P 〈 0.05 ） . Conclusion. The abnormal expression of bcl - xl and bak may be a positive factor in the pathogenesis of lung squamous cell carcinomas. Lung squamous cell carcinomas may result from unbalanced apoptosis.