肿瘤化疗后中性粒细胞缺乏症20例临床分析

Clinical analysis of 20 patients with neutropenic after chemotherapy for cancer

目的:探讨恶性肿瘤患者化疗后中性粒细胞缺乏症的治疗方法。方法:20例中性粒细胞缺乏症患者,一经确诊,立即入住单人病房,严格消毒隔离。使用重组人粒细胞集落刺激因子针(G-CSF)150μg-300μg皮下注射qd连用3-7天升白细胞治疗。19例患者均使用抗生素防治感染,其中14例使用第2、3代头孢菌素+左氧氟沙星治疗。2例使用美罗培南注射剂治疗。结果:20例患者中18例白细胞、中性粒细胞均回升至正常,白细胞回升至正常的时间为3-7日。发热患者经治疗后1-8日体温降至正常,外周血白细胞呈上升之势。结论:使用重组人粒细胞集落刺激因子(G-CSF)皮下注射,辅以第2、3代头孢菌素+左氧氟沙星,及提高机体免疫力等,可有效治疗中性粒细胞缺乏症。

Objective：To explore the treatment of neutropenic after chemotherapy for cancer. Methods： 20 patients with neutropenie after chemotherapy because of cancer, as soon as being diagnosed, entered the single ward in hospital immediately,disinfected strictly by isolation ;filgrastim （G -CSF）150μg- 300μg hypodermic injection to be used for 3 - 7 days. Among them, 19 patients used the antibiotic, 14 patients received 2,3 generation of cephalosporin ＋ levofloxacin, another 2 patients used meropenem. Results： Eighteen patients out of 20 patients turn to normal level after treatments,the neutral granular in peripheral blood cell rose to normal range between 3 -7days. Conclusion： Filgrastim hypodermic injection, plus 2,3 generation of cepalosporin ＋ levofloxacin, enhance ment of immunity treatment is effective and safe in the treatment of neutropenic after chemotherapy for cancer.