摘要
为寻找视网膜色素变性相关基因RP2所在的染色体位点,采用染色体Xp21.1-p11.2区段的8个微卫星DNA标记,对X-连锁RP(XLRP)家系进行连锁分析。家系JG的RP相关位点被定位于X染色体位标DXS1068与DXS1126之间。该区间可能是RP2所在部位,其跨度约5—7cM。可以认为该家系之视网膜色素变性病与RP2基因相关。该家系对寻找和克隆RP2基因非常有用。
To seek the chromosome locus of RP2, a related gene of retinitis pigmentosa(RP), eight microsatellite DNA markers were used for linkage analysis in the XLRP pedigrees. The RP2 locus in family JG was mapped out between the markers DXS1126 and DXS1068 in family JG, which may be 5-7cM apart. This pedigree will be useful in seeking and cloning of RP2 gene.
出处
《高技术通讯》
EI
CAS
CSCD
1998年第9期46-49,共4页
Chinese High Technology Letters
基金
863计划资助项目
国家自然科学基金
关键词
视网膜色素变性
RP2
连锁分析
基因定位
Retinitis Pigmentosa, RP2, Pedigree, Linkage analysis, Microsatellite, Gene mapping