藏波罗花的化学成分研究

Chemical constituents of Incarvillea younghusbandii

目的:对藏药材藏波罗花Incarvillea younghusbandii的化学成分进行分离纯化和结构鉴定。方法:采用正反相硅胶柱色谱和Sephadex LH-20凝胶柱色谱方法进行分离纯化,NMR和MS等波谱方法进行结构鉴定。结果:从藏波罗花的地上部分甲醇提取物中共分离鉴定出15个化合物:异佛手柑内酯(1),6-甲氧基当归素(2),欧前胡素(3),花椒毒内酯(4),珊瑚菜内酯(5),heraclenol(6),rivulobirin A(7),齐墩果酸甲酯(8),咖啡酸甲酯(9),银桦酸(10),boschniakinic acid(11),tert-O-β-D-glucopyranosyl-(R)-heraclenol(12),5-methoxy-8-O-β-D-glucopyranosyloxypsoralen(13),1′-O-β-D-glucopyranosyl-3-hydroxynodakenetin(14)和苯乙醇-O-β-D-吡喃葡萄糖-(1→2)-β-D-吡喃葡萄糖苷(15)。结论:上述化合物均为首次从该植物中分离得到,主要成分为呋喃香豆素类化合物。

Objective： To study the chemical constituents of Incarvillea younghusbandii. Method： The chemical constituents were isolated by various column chromatographic methods and structurally identified by NMR and MS evidence. Result： Fifteen compounds were obtained and identified as isobergapten （ 1 ）, sphondin （ 2）, imperatorin （3）, xanthotoxin （ 4 ）, phellopterin （ 5 ）, heraclenol （6）, rivulobirin A （7）, methyl oleanolate （8）, methyl caffeate （9）, grevillic acid （10）, boschniakinic acid （11）, tert-O-β- D-glucopyranosyl-（ R ）-heraclenol （ 12 ）, 5-methoxy-8-O-β-D-glucopyranosyloxypsoralen （ 13 ）, 1＇-O-β-D-glucopyranosyl-3- hydroxynodakenetin （ 14 ） and phenylethy1-O-β-D-glucopyranosyl- （ 1--2 ） -β-D-glucopyranoside （ 15 ）. Conclusion ： All of these compounds were isolated from this plant for the first time and most of them are furocoumarins.