心舒1号对慢性心力衰竭患者心功能及血浆N末端脑钠肽原的影响

目的观察心舒1号对慢性心力衰竭(CHF)患者血浆N末端脑钠肽原(NT-proBNP)水平的影响及临床疗效。方法选取不同程度慢性心力衰竭患者58例,随机分为治疗组(30例)和对照组(28例),两组均以心力衰竭治疗指南为常规治疗,治疗组在常规治疗基础上口服心舒1号。治疗前及治疗后4周检测左室射血分数(LVEF)、NT-proBNP。结果治疗组有效率93.33%,对照组有效率71.43%。治疗后两组LVEF升高、NT-proBNP水平下降,但治疗组更明显(P<0.05)。结论心舒1号配合西药常规治疗慢性心衰疗效显著。

Objective To observe the effects of XiShul on N-terminal pro-B-type natriuretic peptide （NT--proBNP）in patients with chronic heart failure and the clinical therapeutic effect. Methods A total of 58 patients with CHF, who had already received conventional therapy, were randomly divided into two groups： treatment group （30cases） and control group （28cases）. The patients in treatment group were treated with XiShul on the base of routine therapy. NT--proBNP leves and left ventricular function were analysed before and 4 weeks after treatment. Results The total efficacy of cardiac function was 93.33% in treatment group and 71.43% in control group after treatment （P〈0.05）. After treatment with two groups, NT--proBNP levels were reduced ,while left ventricular function was enhanced （P〈0.05）, However when compared with control group ,the treatment group show significant difference （P〈0.05）. Conclusion XiShulcombined with the conventional therapy is an effective therapy to CHF.