5-苯乙烯基-2-氨基-1,3,4-噻二唑及其席夫碱的合成和表征

Synthesisand Characterization of 2-Amino-5-styryl-1,3,4-thiadiazole and Its Schiff Base

用肉桂酸和氨基硫脲为原料在三氯氧磷催化下合成了5-苯乙烯基-2-氨基-1,3,4-噻二唑及其席夫碱类化合物。通过单因素优选法得出最佳的合成条件是反应物原料的最佳配比为n(硫代氨基脲)∶n(肉桂酸)=1∶1.4,最佳回流时间为4h,并用1HNMR和IR对其结构进行了表征。

An efficient synthesis of 2-amino-5-styryl-1,3,4-thiadiazole and its Schiff base compound was reported from thiosemicarbazide and cinnamic acid using phosphorus oxychloride as catalyst.The factors,which affect the reaction,were investigated and optimized.It was revealed that the best yields were obtained when the molar ratio of the reactants was n（thiosemicarbazide）：n（cinnamic acid）=1：1.4 with refluxing for 4 h.The thiadiazole and corresponding Schiff base are characterized by 1H NMR and IR.