甲状腺相关性眼病活动性检测指标:细胞因子、黏附分子及糖胺聚糖的研究

Active indices of thyroid-associated ophthalmopathy:cytokine,adhesion molecule and glycosaminoglycan

甲状腺相关性眼病是一种与甲状腺疾病相关的器官特异性自身免疫性疾病,其病理表现为大量糖胺聚糖堆积,导致眼球突出,上睑挛缩,复视等临床表现。根据疾病活动性,可以进行活动期与静止期的分类。目前甲状腺相关性眼病活动性评价主要依据患者的症状和体征,以及影像学检查。细胞因子、黏附分子及糖胺聚糖的研究,为甲状腺相关性眼病活动性的客观评价提供了广阔的前景,现做一综述。

Thyroid-associated ophthalmopathy （TAO） is correlated to thyroid disease. Its clinical features are the accumula-tion of glycosaminoglycan（GAG）, exophthalmos, upper eyelid retraction and diplopia. TAO have active and inactive stage according to symptoms, signs and other assistant examinations, but all of the examinations have the influence of patients and doctors. In recent years, the researches of cytokine, adhesion molecule and GAG give extensive prospect in TAO. This paper reviewed the value of cytokine, adhesion molecule and GAG in thyroid-associated ophthalmopathy.