摘要
以氯化三乙基苄基铵(TEBA)为相转移催化剂,1—苯基—2—丙酮、氯仿、α-笨乙胺(1a～c)和氢氧化钾在-5～-10℃于二氯甲烷-水中反应。产物2a—c经氢解、水解得到光学活性2-甲基笨丙氨酸(4a～c),并对影响光学纯度的因素进行了探讨。
The reaction of 1-phenyl-2-propanone, chloroform, a-methylbenzyl amine(la～c), and potassium hydroxide was carried out in dichloromethane-wanter at—5～—10℃, with triethylbenzylammonium chloride as the phase transfer catalyst. The reaction products 2a～c were hydrogenolyzed and hydrolyzed to yield the corresponding optically active 2-methyphenylalanine(4a～c).The effect of optical purity was discussed.
出处
《南京大学学报（自然科学版）》
CAS
CSCD
1990年第4期667-674,共8页
Journal of Nanjing University（Natural Science）
基金
国家自然科学基金资助课题
关键词
不对称诱导
苯基丙酮
甲基苯丙氨酸
asymmetric induction
phase transfer catalyzed reaction
1-phenyl-2-propanone
2-methylphenylalanine
