摘要
目的探讨CD147在宫颈癌中的表达及其意义。方法应用蛋白印迹及免疫组织化学方法检测CD147在宫颈癌和正常宫颈组织中的表达。结果CD147蛋白在所有的宫颈癌(41/41,100.0%)和绝大多数正常宫颈组织(11/12,91.7%)都表达。宫颈组织中存在着不同分子量的CD147分子。CD147在宫颈癌中的细胞阳性率及表达量都要显著高于正常组织(P<0.05)。结论CD147是细胞增殖的一个标记分子;CD147蛋白在宫颈癌中高表达,是宫颈癌治疗的一个潜在靶点。
Objective To investigate the expression of CD147 and its significance in human cervical carcinoma. Methods Western blotting and immunohistochemical staining were used to detect CD147 expression in cervical cancer or normal cervix uteri tissues. Results CD147 protein was expressed in all of cervical carcinomas （41/41, 100.0%） and most of normal cervix uteri tissues （11/12, 91.7%）. CD147 with different molecular weights were present in cervical tissues. The percentage of CD147-positive cells and the expressional level of CD147 were higher in cervical carcinomas than in normal cervix （P〈0.05）. Conclusion CD147 might be recognized as a marker of cell proliferation. High expression of CD147 in cervical carcinomas suggests that it might be a potential target for cervical carcinoma therapy.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第1期14-16,25,共4页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
国家自然科学基金资助项目(No.30571951)
国家自然科学杰出青年基金项目(No.30725043)
教育部985-2期工程(肿瘤干细胞研究)~~
关键词
CD147
宫颈癌
蛋白印迹
免疫组化
CD147
cervical carcinoma
Western blotting
immunohistochemical staining
