小儿MP感染血清细胞因子、hs-CRP及免疫球蛋白的变化

Alteration of Serum Cytokines,High-sensitivity C-reactive Protein and Immunoglobulin in Mycoplasma Pneumonia Infection in Children

目的探讨检测肺炎支原体(MP)感染患儿血清细胞因子、高敏C-反应蛋白及免疫球蛋白的临床意义。方法56例MP感染患儿和58例健康儿童为研究对象,测定血清白细胞介素IL-2、IL-6、IL-8、IL-12,hs-CRP和IgA、IgM、IgG。结果观察组血清IL-2、IL-12和IgA的水平与对照组比较显著降低;观察组血清IL-6、IL-8、hs-CRP、IgM、IgG水平与对照组比较显著上升。结论检测炎性细胞因子、hs-CRP的变化及血清免疫球蛋白对判定病情和预后有一定的临床应用价值。

Objective To investigate the clinical significance of the detection of serum cytokines,high-sensitivity C-reactive protein （hs-CRP）and immunoglobulin level in children with mycoplasma pneumoniae（MP） infection. Methods There were 56 children with MP infection and 58 healthy children in the present study. The serum IL-2,IL-6,IL-Sand IL-12 and hs-CRP and lgA,IgM and IgG were detected. Results The levels of the serum IL-2 andlL-12 and IgA in the observation group were lower than those of the control group. The levels of the serum IL-6 and IL-8 and hs-CRP and IgM and IgG in the observation group were higher than those of the control group. Conclusion It is of important significance to detect the serum cytokines, hs-CRP and immunoglobulin levels in children with MP infection.