IL-10对感染口蹄疫病毒的树突状细胞的影响

The Effects of IL-10 on Dendritic Cells Infected by Foot-and-mouth Virus

树突状细胞(dendritic cells,DC)是机体中重要的抗原递呈细胞,在病毒感染机体后的免疫调节过程中具有重要作用。为研究调节IL-10的分泌是否会影响DC感染病毒后的免疫反应,本研究用FMDV感染DC后发现,IL-10的分泌量可以影响DC在免疫过程中各种细胞因子的表达,故认为IL-10在口蹄疫病毒感染过程中对机体的免疫调节具有重要的影响。

Dendritic cells（DC） are the most potent antigen presenting cells（APC） of the immune system,so it has a special place in induce of immune response.We thought that IL-10 have important effects through the process of viral infection.In this research the IL-10 and IL-10 neutralizing antibody were used to regulate the immune state of DCs when they were infected by FMDVs,the results showed that IL-10 can affect the immune regulation in the course of FMDV infection.