真性红细胞增多症患者的血液流变学特性及口服长效阿司匹林的影响

The Character of Hemorheological Factors in Polycythemia Vera and Effects of Long-Acting Oral Taking of Aspirin

目的了解真性红细胞增多症患者的血液流变学特性变化，研究其并发症的发病机理和寻找预防和治疗的方法。方法通过对真性红细胞增多症患者的血液流变学特性的研究，并和口服长效阿司匹林后进行对比。结果发现真性红细胞增多症病人的血液流变学指标，尤其是全血粘度、全血还原粘度、红细胞聚集和变形能力等和正常对照组相比均有明显的升高；服用长效阿司匹林后这些指标有不同程度的下降。结论真性红细胞增多症病人的红细胞增多导致血液流变学指标的异常升高，口服长效阿司匹林能降低这些异常指标，对预防其并发症有一定的作用。

Objective To understand the changes ofhemorheological factors in these patients with in Polycythemia Vera and study its pathology in order to find the preventive and treating methods.Methods We tested the of hemorheological factors in these patients with Polycythemia Vera,and compareed these factors with cases who oral took long-acting Aspirin.Results We found that the hemorheological factors in patients with Polycythemia Vera, such as whole blood viscosity, reductive whole blood viscosity, red cell aggregation and deformation activity higher than in normal control significantly.Oral taking long-acting Aspirin could improve the abnormal changes of hemorheological parameters.Conclusion Because of the increasing of red cell the hemorheological parameters become much high than in normal patients.