期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

不同剂量阿托伐他汀对老年急性冠脉综合征患者血清高敏C-反应蛋白的影响

下载PDF
导出
摘要 目的探讨不同剂量阿托伐他汀对老年急性冠脉综合征（ACS）患者血清高敏C-反应蛋白（hs-CRP）和血脂水平的影响。方法将77例老年急性冠脉综合征患者随机分成两组，分别应用10mg和40mg阿托伐他汀治疗8周，于治疗前后分别检测患者血清高敏C-反应蛋白和血脂水平。结果（1）两组治疗后，高敏C-反应蛋白明显低于治疗前（P〈0．01）。（2）两组治疗4周与8周后，40mg阿托伐他汀组与10mg阿托伐他汀组相比，高敏C-反应蛋白明显下降（P〈0．05，P〈0．01）。结论两种剂量阿托伐他汀应用于老年急性冠脉综合征早期均能安全、有效地降低患者高敏C-反应蛋白浓度，40mg阿托伐他汀疗效优于10mg阿托伐他汀。
作者 蒋晓林 孙晓晖 顾宇重 张克智
机构地区 南通大学附属医院分院
出处 《中国血液流变学杂志》 CAS 2009年第4期551-552,共2页 Chinese Journal of Hemorheology
关键词 急性冠脉综合症 高敏 C-反应蛋白 阿托伐他汀 老年
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献7

  • 1牛楠.炎症与急性冠脉综合征[J].心血管病学进展,2003,24(2):137-139. 被引量：18
  • 2Yeh ET, Anderson HV,Pasceri V,et al.C-reactive protein: linking inflammation to cardiovascular complications[J]. Circulation,2001,104(9):974-975.
  • 3高润霖.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志,2001,29(12):710-725. 被引量：4952
  • 4Kohchi K, Takebayashi S, Hiroki T, at al.Significance of adventitial inflammation of the coronary artery in patients with unstable argina:results at autopsy[J]. Circulation,1985, 71 (4):709-716.
  • 5Heinrich J, Schulte H, Schonfeld R, at al.Association of Variables of coagulation,fibrinolysis and acute -phase with atherosclerosis in coronary and peripheral arteries and those arteries supplying the brain [J].Thromb Haemost,1995,73 (3):374-379.
  • 6辛怀玉,王守栋,黄海真.他汀类药物在缺血性心血管疾病中非降脂作用的临床价值[J].医学综述,2005,11(1):61-63. 被引量：16
  • 7Pedersen TR,Olsson AG,Faergeman O,et al.Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S)[J].Circulation, 1998,97:1453-1460.

二级参考文献54

  • 1[1]Davies MJ. A macro and micro view of coronary vascular insult in ischemic heart disease [ J ]. Circulation, 1990,82: Ⅱ 38- Ⅱ 46.
  • 2[2]Kinlay S, Selwyn AP, Delagrange D, et al. Biological mechanisms for the clinical success of lipid-lowering in coronary artery disease and the use of surrogate end-points[J]. Curr Opin Lipidol,1996,7:389-397.
  • 3[3]Davies M J, Rachardson PD, Woolf N, et al. Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage and smooth muscle cell content[ J ]. Br Heart J, 1993,69:377-381.
  • 4[4]Sato T, Takebayashi S, Kohchi K. Increased subendothelial infiltration of the coronary arteries with monocytes/macrophages in patients with unstable angina[J]. Atherosclerosis, 1987,68:191-197.
  • 5[5]Moreno PR, Falk E, Palacios IF, et al. Macrophage infiltration in acute coronary syndromes: implications for plaque rupture [J]. Circulation, 1994,90: 775-778.
  • 6[6]van der Wal AC, Becker AE, van der Loos CM, et al. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology[J]. Circulation, 1994,89:36-44.
  • 7[7]Frieman GD, Klatsky AL. Siegelaub AB. The leukocyte count as a predictor of myocardial infaretion[J]. N Engt J Med,1974,290:1275-1278.
  • 8[8]Kostis JB, Turkevich D, Sharp J. Association between leukocyte count and the presence and extent of coronary atherosclerosis as determined by coronary angiography[ J ]. Am J Cardiol, 1984,53:997-999.
  • 9[9]Smith CW, Rothlein R, Hughes B J, et al. Recognition of the endothelial determinant of CD1s-dependent human neutrophil adherence and transendothelial migration[J]. J Clin Invest,1988,82:1746-1756.
  • 10[10]Tonnesen MG, Smedly LA, Henson PM. Neutrophil-endothelial cell interactions[J]. J Clin Inbest,1984,74:158-192.

共引文献4981

中国血液流变学杂志
2009年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部