热休克蛋白70在血管性认知功能损害患者中的表达

Expression of Heat Shock Protein 70 in Vascular Cognitive Impairment Patients

目的探讨热休克蛋白70（HSP70）与血管性认知功能损害（VCI）的关系。方法按蒙特利尔认知评估量表（MoCA）评分结果分组，即认知功能正常组（NCI组，n=S2）和VCI组（n=129），分别用酶联免疫吸附试验（ELASA）测定血浆HSP70浓度。结果NCI组和VCI组患者血浆HSP70浓度分别为11．29±2．66ng／mL和19．92±5．98ng／mL，差异有统计学意义（P〈0．01）；相关性分析显示，VCI患者血浆HSP70浓度与MoCA得分呈负相关（r=-0.742，P〈0．01）组。结论血浆HSP70浓度测定有可能作为观察VCI患者认知功能损害程度的生化指标。

Objective To explore the relationship between heat shock protein 70（HSP70） and vascular cognitive impairment（VCI）.Methods To test cognitive function by Montreal Cognitive Assessment（MoCA）, 181 patients were divided into not cognitively impaired （NCI,n=52）and VCI （n=129） groups;Serum HSP70 levels in the two groups were detected by enzyme linked immunosorbent assay（ELISA）.Results The serum HSP70 levels in the NCI and VCI groups were 11.29 ± 2.66ng/mL and 19.92 ± 5.98ng/mL,respectively.There were significant difference （P〈0.01）.The correlation analysis revealed that the serum HSP70 levels were negatively correlated with the total MoCA scores（r=-0.742,P〈0.01）.Conclusions HSP70 levels may be used as the biochemical indicators for observing vascular cognitive impairment.